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Test Code DABIE Dabigatran, Ecarin, Plasma


Advisory Information


This test measures dabigatran only. For measurement of aragatroban direct thrombin inhibitor, see ARGAT / Argatroban, Ecarin, Plasma.

 

This test is not indicated for monitoring low molecular weight heparin (LMWH), unfractionated heparin (UFH), or oral direct anti-Xa inhibitors (eg, apixaban, rivaroxaban, edoxaban). For monitoring oral direct anti-Xa inhibitors, see APIXA / Apixaban, Anti-Xa, Plasma; EDOXA / Edoxaban, Anti-Xa, Plasma, or RIVAR / Rivaroxaban, Anti-Xa, Plasma.



Necessary Information


If priority specimen, mark request form, give reason, and request a call-back.



Specimen Required


Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Specimen should be drawn 1 to 3 hours (peak) after a dose or just prior (trough) to the next dose for dabigatran concentrations.

2. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing in Special Instructions.

3. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.

4. Aliquot plasma into a plastic vial leaving 0.25 mL in the bottom of centrifuged vial.

5. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, ≤-40° C.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.


Useful For

Measuring dabigatran concentration in plasma

 

This assay is not useful for measurement of other direct thrombin inhibitors eg, argatroban or bivalirudin.

Method Name

Chromogenic Assay

Reporting Name

Dabigatran, Ecarin, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 42 days

Reference Values

<20 ng/mL

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DABIE Dabigatran, Ecarin, P In Process

 

Result ID Test Result Name Result LOINC Value
DABI1 Dabigatran, Ecarin, P 74220-5
DABI2 Interpretation 69049-5
DABI3 Cautions 62364-5

Forms

If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.