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Test Code EDOXA Edoxaban, Anti-Xa, Plasma


Advisory Information


This assay is not indicated for monitoring low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) concentrations. The presence of UFH and LMWH will cause the edoxaban anti-Xa level to be falsely elevated.



Necessary Information


If priority specimen, mark request form, give reason, and request a call-back.



Specimen Required


Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Polypropylene vial

Specimen Volume: 1 mL

Collection Instructions:

1. Specimen should be drawn 1 to 3 hours (peak) after a dose or just prior (trough) to the next dose for edoxaban concentrations.

2. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing in Special Instructions.

3. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.

4. Aliquot plasma into a plastic vial leaving 0.25 mL in the bottom of centrifuged vial.

5. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, ≤-40° C.

Additional Information:

1. A double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.


Useful For

Measuring edoxaban concentration in plasma

 

This test is not useful for monitoring low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) concentrations.

Method Name

Chromogenic Assay

Reporting Name

Edoxaban, Anti-Xa, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL plasma

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 42 days

Reference Values

<10 ng/mL

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
EDOXA Edoxaban, Anti-Xa, P In Process

 

Result ID Test Result Name Result LOINC Value
EDOX1 Edoxaban, Anti-Xa, P In Process
EDOX2 Interpretation 69049-5
EDOX3 Cautions 62364-5

Forms

If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.