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Test Code NICRU Nickel/Creatinine Ratio, Random, Urine

Reporting Name

Nickel/Creat Ratio, Random, U

Useful For

Preferred specimen type for biomonitoring nickel exposure

Profile Information

Test ID Reporting Name Available Separately Always Performed
NICR Nickel/Creat Ratio, U No Yes
CDCR Creatinine Conc No Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Advisory Information

This test is preferred for the determination of nickel exposure but serum concentrations can be used to verify an elevated urine concentration. For more information see NIS / Nickel, Serum.

Specimen Required

Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen

2. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-17 years: not established

Males ≥18 years: <3.8 mcg/g creatinine

Females ≥18 years: <4.3 mcg/g creatinine

Day(s) and Time(s) Performed

Thursday; 8 a.m.

CPT Code Information

83885 Nickel Concentration

82570 Creatinine Concentration

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NICRU Nickel/Creat Ratio, Random, U 13472-6


Result ID Test Result Name Result LOINC Value
CDCR Creatinine Conc 2161-8
32875 Nickel/Creat Ratio, U 13472-6

Method Name

NICR: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

CDCR: Enzymatic Colorimetric Assay

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.