Sign in →

Test Code RETZ RET Proto-Oncogene, Full Gene Analysis

Useful For

Confirmation of suspected clinical diagnosis of multiple endocrine neoplasia type A or B, Hirschsprung disease, or congenital central hypoventilation syndrome in patients with a suspected diagnosis of any of these conditions


Identification of familial RET mutation to allow for predictive or diagnostic testing in family members

Method Name

Polymerase Chain Reaction (PCR) Amplification Followed by DNA Sequencing

Reporting Name

RET Gene, Full Gene Analysis

Specimen Type


Shipping Instructions

Specimen preferred to arrive within 96 hours of draw.

Specimen Required

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call Mayo Medical Laboratories for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood


Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Specimen Stability Information: Ambient (preferred)/Refrigerated

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Varies Ambient (preferred)

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Performed weekly, varies

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81406- RET (ret proto-oncogene) (eg, Hirschsprung disease), full gene sequence

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RETZ RET Gene, Full Gene Analysis 40693-4


Result ID Test Result Name Result LOINC Value
53108 Result Summary 50397-9
53109 Result 21733-1
53110 Interpretation 69047-9
53111 Additional Information 48767-8
53112 Specimen 31208-2
53113 Source 31208-2
53114 Released By 18771-6


1. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.

2. Molecular Genetics: Congenital Inherited Diseases Patient Information (T521) in Special Instructions

3. If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen (