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Test Code Z1409 Proteinase 3 Antibodies, IgG, Serum

Additional Codes


Reporting Name

Proteinase 3 Ab (PR3), S

Useful For

Evaluating patients suspected of having Wegener granulomatosis (WG)


Distinguishing between WG and other forms of vasculitis, in conjunction with:

-MPO / Myeloperoxidase Antibodies, IgG, Serum

-ANCA / Cytoplasmic Neutrophil Antibodies, Serum (may be obtained as VASC / Antineutrophil Cytoplasmic Antibodies Vasculitis Panel, Serum)


May be useful to follow treatment response or to monitor disease activity in patients with myeloperoxidase antibodies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.35 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

<0.4 U (negative)

0.4-0.9 U (equivocal)

≥1.0 U (positive)

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Saturday; 4 p.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PR3 Proteinase 3 Ab (PR3), S 74106-6


Result ID Test Result Name Result LOINC Value
PR3 Proteinase 3 Ab (PR3), S 74106-6

Method Name

Multiplex Flow Immunoassay


If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.