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HelpTest Code 8887 HER2/neu (c-erbB2), Immunoperoxidase Stain
Additional Codes
| Ordering Mnemonic |
|---|
| HER2 |
Methodology
FDA-Approved HercepTestTM Immunoperoxidase Stain
Performing Laboratory
Holland Hospital Laboratory Services
Specimen Requirements
Container/Tube: Paraffin-embedded tissue block
Specimen Volume: See “Container/Tube.”
Forms: “Histopathology/Cytology” request form. See Special Instructions for a copy of the form.
Collection Instructions:
Note: 1. HER2 protein immunohistochemical test results are only valid for non-decalcified, paraffin-embedded specimens fixed in neutral buffered formalin. For optimal results, tissue must be fixed for a minimum of 6 hours and a maximum of 72 hours in fresh, neutral-buffered formalin. This test is FDA-approved only for specimens fixed using 10% formalin.
2. If HER2/neu score is weakly positive, score 2+, specimen will be sent to Spectrum Health Laboratories for “HER2 Amplification Associated with Breast Cancer, FISH” and will be performed and charged accordingly to determine HER2/neu amplification.
Specimen Transport Temperature
Ambient
Day(s) Test Set Up
Monday through Friday
Test Classification and CPT Coding
88342
Reference Values
Reported as negative (0, 1+), weakly positive (2+), and strongly positive (3+) according to the interpretation guidelines in the FDA-approved HercepTestTM.