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Test Code ALDNA Aldosterone with Sodium, 24 Hour, Urine

Reporting Name

Aldosterone with Sodium, Urine

Useful For

Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome)

Profile Information

Test ID Reporting Name Available Separately Always Performed
ALDU Aldosterone, U Yes Yes
NAU Sodium, U Yes Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Specimen Required


Container/Tube: 2 Plastic, 5-mL tubes (T465)

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old. This preservative is intended to achieve a pH of between approximately 2 and 4.

3. Place 5 mL of well mixed, 24-hour urine in plastic, 5-mL tube (T465) and label as Aldosterone.

4. Place 5 mL of well mixed, 24-hour urine in plastic, 5-mL tube (T465) and label as Sodium.

Additional Information:

1. 24-Hour volume is required.

2. See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens and Renin-Aldosterone Studies for more detailed instructions in Special Instructions.


Specimen Minimum Volume

Aldosterone: 1 mL/Sodium: 1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  7 days

Reference Values

ALDOSTERONE

0-30 days: 0.7-11.0 mcg/24 hours*

1-11 months: 0.7-22.0 mcg/24 hours*

≥1 year: 2.0-20.0 mcg/24 hours

 

*Loeuille GA, Racadot A, Vasseur P, Vandewalle B: Blood and urinary aldosterone levels in normal neonates, infants and children. Pediatrie 1981;36:335-344

 

SODIUM

41-227 mmol/24 hours

If the 24-hour urinary sodium excretion is >200 mmol, the urinary aldosterone excretion should be <10 mcg.

Day(s) and Time(s) Performed

Aldosterone: Monday, Thursday; 3 p.m.

Sodium: Monday through Sunday; Continuously

CPT Code Information

82088-Aldosterone

84300-Sodium

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ALDNA Aldosterone with Sodium, Urine 94871-1

 

Result ID Test Result Name Result LOINC Value
NA_24 Sodium, 24 Hr, U 2956-1
8556 Aldosterone, U 1765-7
TM47 Collection Duration 13362-9
TM11 Collection Duration 13362-9
VL9 Urine Volume 3167-4
VL45 Urine Volume 3167-4
NACN Sodium Concentration 21525-1

Method Name

ALDU: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

NAU: Potentiometric, Indirect Ion-Selective Electrode (ISE)

Urine Preservative Collection Options

Ambient

OK

Refrigerate

OK

Frozen

OK

50% Acetic Acid

Preferred

Boric Acid

OK

Diazolidinyl Urea

No

6M Hydrochloric Acid

No

6M Nitric Acid

No

Sodium Carbonate

No

Thymol

No

Toluene

No

 

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.