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Test Code BCGRV Immunoglobulin Gene Rearrangement, Varies

Reporting Name

Immunoglobulin Gene Rearrange, V

Useful For

Determining whether a B-cell or plasma cell population is polyclonal or monoclonal in specimens other than blood or bone marrow

 

Identifying neoplastic cells as having B-cell or plasma cell differentiation

 

Monitoring for a persistent neoplasm by detecting an immunoglobulin gene rearrangement profile similar to that from a previous neoplastic specimen

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Varies


Shipping Instructions


Body fluid or spinal fluid must arrive within 4 days (96 hours) of collection.



Specimen Required


Submit only 1 of the following specimens:

 

Specimen Type: Body fluid

Container/Tube: Sterile container

Specimen Volume: At least 5 mL

Collection Instructions:

1. If the volume is large, pellet cells prior to sending.

2. Send less volume at ambient temperature or as a frozen cell pellet.

Specimen Stability Information:

Body Fluid: Ambient/Refrigerated/Frozen

Cell Pellet: Frozen

 

Specimen Type: Paraffin-embedded bone marrow aspirate clot

Container/Tube: Paraffin block

Specimen Stability Information: Ambient 

 

Specimen Type: Frozen tissue

Container/Tube: Plastic container

Specimen Volume: 100 mg

Collection Instructions: Freeze tissue within 1 hour of collection.

Specimen Stability Information: Frozen

 

Specimen Type: Paraffin-embedded tissue

Container/Tube: Paraffin block

Specimen Stability Information: Ambient

 

Specimen Type: Tissue

Slides: Unstained slides

Specimen Volume: 10 Slides

Specimen Stability Information: Ambient

 

Specimen Type: Spinal fluid

Container/Tube: Sterile vial

Specimen Volume: 5-10 mL

Specimen Stability Information: Ambient/Refrigerated

 

Specimen Type: Extracted DNA from blood or bone marrow

Container/Tube: 1.5- to 2-mL tube

Specimen Volume: Entire specimen

Collection Instructions: Label specimen as extracted DNA from blood or bone marrow and provide indication of volume and concentration of DNA

Specimen Stability Information: Refrigerated/Ambient


Specimen Minimum Volume

Body and spinal fluid: 1 mL
Tissue: 50 mg
Extracted DNA from blood or bone marrow: 50 microliters (mcL) at 20 ng/mcL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81261-IGH (Immunoglobulin heavy chain locus) (eg, leukemias and lymphomas B-cell), gene rearrangement analysis to detect abnormal clonal populations; amplified methodology (eg. polymerase chain reaction)

81264-IGK (Immunoglobulin kappa light chain locus) (eg, leukemia and lymphoma, B-cell) gene rearrangement analysis, evaluation to detect abnormal clonal populations

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BCGRV Immunoglobulin Gene Rearrange, V 61113-7

 

Result ID Test Result Name Result LOINC Value
MP017 Specimen: 31208-2
19915 Final Diagnosis: 34574-4

Method Name

Genomic DNA Extracted Followed by Polymerase Chain Reaction (PCR)

Testing Algorithm

The following algorithms are available in Special Instructions:

-Gastric MALT Lymphoma Diagnostic Algorithm      

-Gastric MALT Posttherapy Follow-up Algorithm

Forms

1. Hematopathology Patient Information (T676) in Special Instructions

2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.