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Test Code MRDMM Multiple Myeloma Minimal Residual Disease by Flow, Bone Marrow

Advisory Information

MRDMM should be ordered when monitoring Multiple Myeloma patients after treatment. This test should not be ordered on known relapsing patients or at diagnosis, see PCPRO / Plasma Cell DNA Content and Proliferation, Bone Marrow or MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report if indicated for these situations.

Shipping Instructions

It is recommended that specimens arrive within 48 hours of draw.  Draw and package specimen as close to shipping time as possible. 

Necessary Information

1. Include patient's disease state (untreated, treated, monoclonal gammopathy of undetermined significance, stable).

2. Indicate if patient is on anti-CD38 therapy.

3. Provide Immunofix information if available.

Specimen Required

Specimen Type: Redirected bone marrow


Preferred: Yellow top (ACD)

Acceptable: EDTA

Specimen Volume: 4 mL

Useful For

Detection of low level (minimal residual disease) myeloma cells after therapy

Method Name

Immunophenotyping for Minimal Residual Disease (MRD)

Reporting Name

Multiple Myeloma MRD by Flow, BM

Specimen Type

Bone Marrow

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Bone Marrow Ambient (preferred) 72 hours
  Refrigerated  72 hours

Reference Values

An interpretive report will be provided.

This test will be processed as a laboratory consultation. An interpretation of the immunophenotypic findings and correlation with the previous patient history will be provided by a hematopathologist for every case.

Day(s) and Time(s) Performed

Specimens are processed Monday through Sunday.

Results reported Monday through Friday.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

88184-Flow Cytometry; first cell surface, cytoplasmic or nuclear marker

88185 x 9-Flow Cytometry; additional cell surface, cytoplasmic or nuclear marker

88188-Flow Cytometry Interpretation, 9 to 15 Markers

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MRDMM Multiple Myeloma MRD by Flow, BM 93022-2


Result ID Test Result Name Result LOINC Value
CK146 % Minimal Residual Disease (MRD) 93021-4
CK147 % Normal Plasma Cells (of total PC) 93020-6
CK148 Non-Aggregate Events 38257-2
CK149 Total Plasma Cell Events 93019-8
CK150 Poly PC Events 93018-0
CK151 Abnormal PC Events 93017-2
CK152 Final Diagnosis 74226-2


If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.