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Test Code ROMA ROMA Score (Ovarian Malignancy Risk Algorithm)

Useful For

Aids in assessing whether there is a high- or low-likelihood of finding an ovarian malignancy at surgery in women who present with an adnexal mass

Profile Information

Test ID Reporting Name Available Separately Always Performed
HE4R HE4,S Yes, (Order HE4) Yes
CA125 Cancer Ag 125 (CA 125), S Yes, (Order CA25) Yes
ROMA1 Risk Score, if premenopausal No Yes
ROMA2 Risk Score, if postmenopausal No Yes

Reporting Name

ROMA Score

Specimen Type


Specimen Required

Patient Preparation: Specimens should not be collected from patients receiving therapy with high biotin doses (ie, >5 mg/day) until at least 8 hours following the last biotin administration.

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 84 days
  Refrigerated  48 hours

Reference Values


HE4, S

≤140 pmol/L

Cancer Ag 125 (CA 125), S

<46 U/mL

ROMA Score

Premenopausal: <1.14 (low risk)

Postmenopausal: <2.99 (low risk)

Males: Not applicable

Day(s) and Time(s) Performed

Monday through Friday; 6 a.m.-12 a.m.

Saturday; 6 a.m.-6 p.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86305-HE4, S

86304-Cancer Ag 125 (CA 125), S

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ROMA ROMA Score In Process


Result ID Test Result Name Result LOINC Value
HE4R HE4,S 55180-4
CA125 Cancer Ag 125 (CA 125), S 83082-8
ROMA1 Risk Score, if premenopausal 69569-2
ROMA2 Risk Score, if postmenopausal 69570-0


If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen (