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Test Code TCP T-Cell Subsets, Naive, Memory and Activated

Reporting Name

T Cell Phenotyping, Advanced

Useful For

Determining the presence of naive, memory, and activated T cells in various clinical contexts including autoimmune diseases, immunodeficiency states, T-cell recovery posthematopoietic stem cell transplant, DiGeorge syndrome, and as a measure for T-cell immune competence

 

Naive T-cells results can be used as a surrogate marker for thymic-derived T-cell reconstitution, when used in conjunction with assessment of T-cell receptor excision circles (TREC / T-Cell Receptor Excision Circles [TREC] Analysis for Immune Reconstitution)

 

Assessing a patient's relative risk for infections

 

Evaluation of patients with cellular or combined primary immunodeficiencies

 

Evaluation of T-cell reconstitution after hematopoietic stem cell transplant, chemotherapy, biological therapy, immunosuppression or immunomodulator therapy

 

Evaluation of patients with autoimmune diseases

 

Evaluation of HIV-positive patients for naive and memory subsets

 

Evaluation of T-cell immune competence (presence of memory and activated T cells) in patients with recurrent infections

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Whole Blood EDTA


Specimen Required


Specimens are required to be received in the laboratory weekdays and by 4 p.m. on Friday. It is recommended that specimens arrive within 24 hours of draw. Specimens arriving on the weekend may be canceled. Draw and package specimen as close to shipping time as possible.

 

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions: Send specimen in original tube. Do not aliquot.

Additional Information:

1. Ordering physician's name and phone number are required.

2. For serial monitoring, we recommend that specimen draws be performed at the same time of day.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Ambient 72 hours

Reference Values

The appropriate age-related reference values will be provided on the report.

Day(s) and Time(s) Performed

Monday through Friday

Do not send specimen after Thursday. Specimen must be received by 10 a.m. on Friday.

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86359-T cells, total count

86361-Absolute CD4 count

88184-Flow cytometry

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TCP T Cell Phenotyping, Advanced In Process

 

Result ID Test Result Name Result LOINC Value
29151 %CD4+CD45RA+ naive T cells 89360-2
29152 %CD4+CD62L+CD27+ naive T cells 89340-4
29153 %CD8+CD45RA+ naive T cells 82744-4
29154 %CD8+CD62L+CD27+naive T cells 89339-6
29155 %CD4+CD45RO+ memory T cells 89362-8
29156 %CD4+CD62L+CD27+CD45RO+ (Tcm) 89338-8
29157 %CD4+CD62L-CD27-CD45RO+ (Tem) 89337-0
29158 %CD8+CD45RO+ memory T cells 89336-2
29159 %CD8+CD62L+CD27+CD45RO+ (Tcm) 89335-4
29160 %CD8+CD62L-CD27-CD45RO+ (Tem) 89334-7
29161 %Activated CD4 T cells (4+CD25+) 89431-1
29162 %CD4+HLA DR+CD28+ T cells 89333-9
29163 %CD8+HLA DR+CD28+ T cells 89332-1
29164 CD4+CD45RA+ naive T cells 26759-1
29165 CD4+CD62L+CD27+ naive T cells 89331-3
29166 CD8+CD45RA+ naive T cells 82743-6
29167 CD8+CD62L+CD27+naive T cells 89330-5
29168 CD4+CD45RO+ memory T cells 34475-4
29169 CD4+CD62L+CD27+CD45RO+ (Tcm) 89329-7
29170 CD4+CD62L-CD27-CD45RO+ (Tem) 89328-9
29171 CD8+CD45RO+ memory T cells 85790-4
29172 CD8+CD62L+CD27+CD45RO+ (Tcm) In Process
29173 CD8+CD62L-CD27- CD45RO+ (Tem) 89327-1
29174 Activated CD4 T cells (4+CD25+) 26982-9
29175 CD4+HLA DR+CD28+ T cells 89326-3
29176 CD8+HLA DR+CD28+ T cells 89325-5
29178 Interpretation 69052-9

Method Name

Flow Cytometry