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Test Code TOSU Targeted Opioid Screen, Random, Urine


Additional Testing Requirements


In most cases, no additional testing is needed after the qualitative targeted opioid test is performed if the parent/metabolites found are consistent with the patients prescribed medications. However, if unexpected opioid parent/metabolites are found, confirmatory testing can be requested at an additional charge.



Specimen Required


Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Plastic urine container

Submission Container/Tube: Plastic, 5-mL tube

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative


Useful For

Determining compliance or identifying illicit opioid drug use in urine specimens

 

This test is not intended for employment-related testing.

Profile Information

Test ID Reporting Name Available Separately Always Performed
LPPO List prescribed opioids No Yes
TOPSU Targeted Opioid Screen, U No Yes

Method Name

Liquid Chromatography-Tandem Mass Spectrometry, High Resolution Accurate Mass (LC-MS/MS HRAM)

Reporting Name

Targeted Opioid Screen, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

Not Detected

 

Cutoff concentrations:

Codeine: 25 ng/mL

Codeine-6-beta-glucuronide: 100 ng/mL

Morphine: 25 ng/mL

Morphine-6-beta-glucuronide: 100 ng/mL

6-monoacetylmorphine: 25 ng/mL

Hydrocodone: 25 ng/mL

Norhydrocodone: 25 ng/mL

Dihydrocodeine: 25 ng/mL

Hydromorphone: 25 ng/mL

Hydromorphone-3-beta-glucuronide: 100 ng/mL

Oxycodone: 25 ng/mL

Noroxycodone: 25 ng/mL

Oxymorphone: 25 ng/mL

Oxymorphone-3-beta-glucuronide: 100 ng/mL

Noroxymorphone: 25 ng/mL

Fentanyl: 2 ng/mL

Norfentanyl: 2 ng/mL

Meperidine: 25 ng/mL

Normeperidine: 25 ng/mL

Naloxone: 25 ng/mL

Naloxone-3-beta-glucuronide: 100 ng/mL

Methadone: 25 ng/mL

EDDP: 25 ng/mL

Propoxyphene: 25 ng/mL

Norpropoxyphene: 25 ng/mL

Tramadol: 25 ng/mL

O-desmethyltramadol: 25 ng/mL

Tapentadol: 25 ng/mL

N-desmethyltapentadol: 50 ng/mL

Tapentadol-beta-glucuronide: 100 ng/mL

Buprenorphine: 5 ng/mL

Norbuprenorphine: 5 ng/mL

Norbuprenorphine glucuronide: 20 ng/mL

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80364 (G0480 if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TOSU Targeted Opioid Screen, U In Process

 

Result ID Test Result Name Result LOINC Value
LPPO List prescribed opioids 29305-0
42323 Codeine 19411-8
42324 Codeine-6-beta-glucuronide 89310-7
42325 Morphine 19597-4
42326 Morphine-6-beta-glucuronide 89308-1
42327 6-monoacetylmorphine 19321-9
42328 Hydrocodone 19482-9
42329 Norhydrocodone 89304-0
42330 Dihydrocodeine 19446-4
42331 Hydromorphone 19486-0
42332 Hydromorphone-3-beta-glucuronide 89309-9
42333 Oxycodone 19642-8
42334 Noroxycodone 89303-2
42335 Oxymorphone 19646-9
42336 Oxymorphone-3-beta-glucuronide 89301-6
42337 Noroxymorphone 89302-4
42338 Fentanyl 59673-4
42339 Norfentanyl 43199-9
42340 Meperidine 19532-1
42341 Normeperidine 27920-8
42342 Naloxone 42618-9
42343 Naloxone-3-beta-glucuronide 89307-3
42344 Methadone 19550-3
42345 EDDP 93495-0
42346 Propoxyphene 19429-0
42347 Norpropoxyphene 19632-9
42348 Tramadol 19710-3
42349 O-desmethyltramadol 86453-8
42350 Tapentadol 72485-6
42351 N-desmethyltapentadol 89306-5
42352 Tapentadol-beta-glucuronide 89300-8
42353 Buprenorphine 93494-3
42354 Norbuprenorphine 82371-6
42355 Norbuprenorphine glucuronide 89305-7
65059 Opioid Interpretation 69050-3

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.